ea0081p557 | Calcium and Bone | ECE2022
Patera Bohdan
, Martina Bianchi Federica
, Clementi Ilaria
, Maria Fazzino Gaia Francesca
, Lanzo Nicola
, Lepanto Silvia
, Manzella La Barbera Francesca
, Piantanida Eliana
, Tanda Maria Laura
Tumor-induced osteomalacia (TIO) or oncogenic osteomalacia is a rare paraneoplastic disorder, usually resulting from Fibroblast Growth Factor 23 (FGF23) oversecretion by a benign small phosphaturic mesenchymal tumor, causing hypophosphatemia and reduced 1,25-dihydroxyvitamin D synthesis. Calcium and parathyroid hormone (PTH) levels are usually normal, but secondary/tertiary hyperparathyroidism has been reported in up to 5% of the cases, mainly due to 1,...